Article
Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice.
Journal of neurochemistry - 1 Sept 2013
Massey Caitlin A, Kim Gloria, Corcoran Andrea E, Haynes Robin L, Paterson David S, Cummings Kevin J, Dymecki Susan M, Richerson George B, Nattie Eugene E, Kinney Hannah C, Commons Kathryn G
Abstract excerpt
The sudden infant death syndrome is associated with a reduction in brainstem serotonin 5-hydroxytryptamine (5-HT) and 5-HT(1A) receptor binding, yet it is unknown if and how these findings are linked. In this study, we used quantitative tissue autoradiography to determine if post-natal development of brainstem 5-HT(1A) receptors is altered in two mouse models where the development of 5-HT neurons is defective,...
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