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Article

Telomere Length Modulation in Human Astroglial Brain Tumors

14 May 2013

Abstract excerpt

BACKGROUND: Telomeres alteration during carcinogenesis and tumor progression has been described in several cancer types. Telomeres length is stabilized by telomerase (h-TERT) and controlled by several proteins that protect telomere integrity, such as the Telomere Repeat-binding Factor (TRF) 1 and 2 and the tankyrase-poli-ADP-ribose polymerase (TANKs-PARP) complex. OBJECTIVE: To investigate telomere dysfunction in...

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PMID: 23691191
DOI: 10.1371/journal.pone.0064296

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