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Article

Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension.

PloS one - 1 Jan 2013

Kumar Rahul, Kohli Samantha, Alam Perwez, Barkotoky Ritankur, Gupta Mohit, Tyagi Sanjay, Jain S K, Pasha M A Qadar

Abstract excerpt

BACKGROUND: The genes FTO and GNB3 are implicated in essential hypertension but their interaction remains to be explored. This study investigates the role of interaction between the two genes in the pathophysiology of essential hypertension. METHODS/PRINCIPAL FINDINGS: In a case-control study comprising 750 controls and 550 patients, interaction between the polymorphisms of FTO and GNB3 was examined using...

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Topics

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to Epistasis, Genetic

Share to Genetic Loci

Share to Heterotrimeric GTP-Binding Proteins

Share to Hypertension

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Source

Open in PubMed Open full text

Identifiers

PMID: 23691120
DOI: 10.1371/journal.pone.0063934
PMCID: PMC3653800

Genes

FTO
GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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