Article
Tracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences.
PloS one - 1 Jan 2015
Steglich Matthias, Nitsche Andreas, von Müller Lutz, Herrmann Mathias, Kohl Thomas A, Niemann Stefan, Nübel Ulrich
Abstract excerpt
We applied whole-genome sequencing to reconstruct the spatial and temporal dynamics underpinning the expansion of Clostridium difficile ribotype 027 in Germany. Based on re-sequencing of genomes from 57 clinical C. difficile isolates, which had been collected from hospitalized patients at 36 locations throughout Germany between 1990 and 2012, we demonstrate that C. difficile genomes have accumulated sequence...
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