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Article

Chronic BMAA exposure combined with TDP-43 mutation elicits motor neuron dysfunction phenotypes in mice.

Neurobiology of aging - 1 Jun 2023

Arnold F J, Burns M, Chiu Y, Carvalho J, Nguyen A D, Ralph P C, La Spada A R, Bennett C L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with an average age-of-onset of ∼60 years and is usually fatal within 2-5 years of diagnosis. Mouse models based upon single gene mutations do not recapitulate all ALS pathological features. Environmental insults may also contribute to ALS, and β-N-methylamino-L-alanine (BMAA) is an environmental toxin linked with an increased risk of developing...

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Identifiers

PMID: 36931113
DOI: 10.1016/j.neurobiolaging.2023.02.010
PMCID: PMC12906711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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