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Investigational CHK1 inhibitors in early phase clinical trials for the treatment of cancer

29 Nov 2019

Abstract excerpt

Introduction: Checkpoint kinase 1 (CHK1) inhibitors have been in development for two decades. The initial CHK1 inhibitor staurosporine analog, UCN01, entered clinical trials whilst it was still considered to act via PKC inhibition; only later were trials performed in a more focused fashion to determine whether CHK1 inhibition could dysregulate cell cycle checkpoints. Many of the subsequently synthesized more...

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PMID: 31783714
DOI: 10.1080/13543784.2019.1694661

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