Article
Synthetic Poliovirus and Other Designer Viruses: What Have We Learned from Them?
27 Sept 2010
Abstract excerpt
Owing to known genome sequences, modern strategies of DNA synthesis have made it possible to recreate in principle all known viruses independent of natural templates. We describe the first synthesis of a virus (poliovirus) in 2002 that was accomplished outside living cells. We comment on the reaction of laypeople and scientists to the work, which shaped the response to de novo syntheses of other viruses. We...
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