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Poliovirus: Generation, Quantification, Propagation, Purification, and Storage

1 May 2013

Abstract excerpt

Poliovirus (PV) is the prototypical picornavirus. It is a non-enveloped RNA virus with a small (~7.5-kb) genome of positive polarity. It has long served as a model to study RNA virus biology, pathogenesis, and evolution. cDNA clones of several strains are available, and infectious virus can be produced by the transfection of in vitro transcribed viral genomes into an appropriate host cell. PV infects many human...

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PMID: 23686830
DOI: 10.1002/9780471729259.mc15h01s29

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