Article
Common genetic variants of MGP are associated with calcification on the arterial wall but not with calcification present in the atherosclerotic plaques.
Circulation. Cardiovascular genetics - 1 Jun 2013
Wang Yibo, Chen Jinxing, Zhang Yu, Yu Weifeng, Zhang Channa, Gong Ling, Shao Liying, Lu Jinguo, Gao Yang, Chen Xuannan, Chen Xi, Hui Rutai
Abstract excerpt
BACKGROUND: Two endophenotypes of arterial calcification, calcification on arterial wall and calcification in atherosclerotic plaques, are associated with different types of cardiovascular events. Mgp-deficient mice showed matrix Gla protein (MGP) is strongly associated with calcification on arterial wall without atherosclerotic plaques, and MGP variants were not significantly associated with myocardial...
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