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Article

Multi-system dysregulation in placental malaria contributes to adverse perinatal outcomes in mice

5 Jun 2025

Abstract excerpt

ABSTRACT Sequestration of Plasmodium parasites in the placental vasculature contributes to increased morbidity and mortality in pregnant compared to non-pregnant patients in malaria-endemic regions. In this study, outbred pregnant CD1 mice with semi-allogeneic fetuses were infected with transgenic Plasmodium berghei or mock inoculated by mosquito bite at either embryonic day (E)6 (first trimester-equivalent) or...

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PMID: 40470930
DOI: 10.1128/iai.00021-25

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