Article
Diphtheria toxin mutant selectively kills cerebellar Purkinje neurons.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Riedel C J, Muraszko K M, Youle R J
Abstract excerpt
CRM107 (crossreacting material 107), a double point mutant of diphtheria toxin that lacks receptor-binding activity, specifically kills cerebellar Purkinje cells in vivo. After injection into guinea pig cerebrospinal fluid, CRM107 (0.9 micrograms) and CRM107-monoclonal antibody conjugates (10 micrograms) kill up to 90% of the total Purkinje cell population with no detectable toxicity to other neurons. Animals...
Topics
- Animals
- Antibodies, Monoclonal
- Bacterial Toxins
- Cerebellum
- Diphtheria Toxin
- Female
- Guinea Pigs
- Immunotoxins
- Injections, Spinal
- Mutation
- Nervous System Diseases