Article
Neuropathy in miniature swine after administration of the mutant diphtheria toxin-based immunotoxin, pCD3-CRM9.
Transplantation - 15 Sept 2001
Gargollo P, Yamada K, Esnaola N, Fuchimoto Y, Newell K L, Sachs D H, Huang C A
Abstract excerpt
BACKGROUND: Effective in vivo T-cell depletion is a critical component of many transplantation tolerance protocols. We have previously demonstrated T-cell depletion in miniature swine using a CRM9-based CD3-immunotoxin, pCD3-CRM9. CRM9 is a mutant form of diphtheria toxin (DT) that binds less efficiently than wild-type DT to the DT receptor (proHB-EGF) of primates. In this report, we describe and characterize the...
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