Article
Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.
Developmental cell - 13 May 2013
Lettman Molly M, Wong Yao Liang, Viscardi Valeria, Niessen Sherry, Chen Sheng-Hong, Shiau Andrew K, Zhou Huilin, Desai Arshad, Oegema Karen
Abstract excerpt
Assembly of SAS-6 dimers to form the centriolar cartwheel requires the ZYG-1/Plk4 kinase. Here, we show that ZYG-1 recruits SAS-6 to the mother centriole independently of its kinase activity; kinase activity is subsequently required for cartwheel assembly. We identify a direct interaction between ZYG-1 and the SAS-6 coiled coil that explains its kinase activity-independent function in SAS-6 recruitment....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.