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Article

Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap complex patterns mammalian CNS.

Developmental cell - 13 May 2013

Lanctot Alison A, Peng Chian-Yu, Pawlisz Ashley S, Joksimovic Milan, Feng Yuanyi

Abstract excerpt

Regulating cell proliferation and differentiation in CNS development requires both extraordinary complexity and precision. Neural progenitors receive graded overlapping signals from midline signaling centers, yet each makes a unique cell fate decision in a spatiotemporally restricted pattern. The Nde1-Lis1 complex regulates individualized cell fate decisions based on the geographical location with respect to the...

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Identifiers

PMID: 23673330
DOI: 10.1016/j.devcel.2013.04.006
PMCID: PMC3718043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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