Article
The effect of decellularization of tracheal allografts on leukocyte infiltration and of recellularization on regulatory T cell recruitment.
Biomaterials - 1 Jul 2013
Haykal Siba, Zhou Yingzhe, Marcus Paula, Salna Michael, Machuca Tiago, Hofer Stefan O P, Waddell Thomas K
Abstract excerpt
Tracheal transplantation without immunosuppressive therapy has been accomplished with a tissue-engineering approach using decellularized biological scaffolds in combination with recipient progenitor cells. The mechanisms of immune response directed towards these tracheal allografts have not been fully determined. In this study, we evaluated the immunogenicity of these grafts at the protein level, and...
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