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Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization

9 May 2013

Abstract excerpt

Serum characterization and antibody isolation are transforming our understanding of the humoral immune response to viral infection. Here, we show that epitope specificities of HIV-1-neutralizing antibodies in serum can be elucidated from the serum pattern of neutralization against a diverse panel of HIV-1 isolates. We determined "neutralization fingerprints" for 30 neutralizing antibodies on a panel of 34 diverse...

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PMID: 23661761
DOI: 10.1126/science.1233989

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