Article
Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2013
Robciuc Marius R, Maranghi Marianna, Lahikainen Anna, Rader Daniel, Bensadoun Andre, Öörni Katariina, Oörni Katariina, Metso Jari, Minicocci Ilenia, Ciociola Ester, Ceci Fabrizio, Montali Anna, Arca Marcello, Ehnholm Christian, Jauhiainen Matti
Abstract excerpt
OBJECTIVE: Angiopoietin-like 3 (Angptl3) is a regulator of lipoprotein metabolism at least by inhibiting lipoprotein lipase activity. Loss-of-function mutations in ANGPTL3 cause familial combined hypolipidemia through an unknown mechanism. APPROACH AND RESULTS: We compared lipolytic activities, lipoprotein composition, and other lipid-related enzyme/lipid transfer proteins in carriers of the S17X loss-of-function...
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