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Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase

10 May 2013

Abstract excerpt

UNLABELLED: Overexpression of the oncoprotein Aurora A kinase occurs in multiple types of cancer, often early during cell transformation. To identify the mechanism(s) contributing to enhanced Aurora A protein expression, a comparison between normal human lung fibroblast and breast epithelial cells to nontumorigenic breast (MCF10A and MCF12A) and tumorigenic breast (MCF-7) and cervical cell lines (HeLa S3) was...

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PMID: 23661421
DOI: 10.1158/1541-7786.mcr-12-0707

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Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A KinasePMID 23661421Read ↗

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