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Article

Internal ribosome entry site-based vectors for combined gene therapy

1 Jan 2015

Abstract excerpt

Gene therapy appears as a promising strategy to treat incurable diseases. In particular, combined gene therapy has shown improved therapeutic efficiency. Internal ribosome entry sites (IRESs), RNA elements naturally present in the 5' untranslated regions of a few mRNAs, constitute a powerful tool to co-express several genes of interest. IRESs are translational enhancers allowing the translational machinery to...

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RNA Interference and Gene Delivery
Viral Infections and Immunology Research
Virus-based gene therapy research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25699230
DOI: 10.5493/wjem.v5.i1.11

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