Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism.

Experimental cell research - 15 Jul 2013

Matteucci Emanuela, Maroni Paola, Bendinelli Paola, Locatelli Alessia, Desiderio Maria Alfonsina

Abstract excerpt

Here, we report a complex regulation of endothelin-1 (ET-1) axis driven by epigenetic reactions in 1833-bone metastatic cells, emphasizing the importance in skeletal metastasis from breast carcinoma. Inhibitors of histone deacetylases, trichostatin A (TSA), and of DNA methylases, 5'-Azacytidine (...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azacitidine
Share to Dactinomycin
Share to Endothelin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Hydroxamic Acids

Share to Peptides, Cyclic

Share to Proto-Oncogene Protein c-ets-1

Share to Receptor, Endothelin A

Source

Identifiers

PMID: 23660387
DOI: 10.1016/j.yexcr.2013.04.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23660387-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism.PMID 23660387Read ↗

Comparative role of acetylation along c-SRC/ETS1 signaling pathway in bone metastatic and invasive mammary cell phenotypes.Semantic proximity Read ↗

NF-kappaB activation, dependent on acetylation/deacetylation, contributes to HIF-1 activity and migration of bone metastatic breast carcinoma cells.Semantic proximity Read ↗

β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.Semantic proximity Read ↗

Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumorsSemantic proximity Read ↗

Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells.Semantic proximity Read ↗

The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line modelSemantic proximity Read ↗

Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancerSemantic proximity Read ↗

Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor.Semantic proximity Read ↗

A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells.Semantic proximity Read ↗

Activation of Antimetastatic Nm23-H1 Gene Expression by Estrogen and Its α-ReceptorSemantic proximity Read ↗

Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-κB in human osteosarcomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.