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Article

Activation of Antimetastatic Nm23-H1 Gene Expression by Estrogen and Its α-Receptor

1 Feb 2002

Abstract excerpt

Metastasis of various malignant cells is inversely related to the abundance of the Nm23-H1 protein. The role of estrogens in tumor metastasis has now been investigated by examining the effect of E2 on the expression of the Nm23-H1 gene. Three human breast carcinoma cell lines, in which endogenous ERalpha is expressed at different levels, were used as a tool to assess the role of ERalpha in Nm23-H1 gene-mediated...

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PMID: 11796500
DOI: 10.1210/endo.143.2.8620

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