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Article

Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer

15 Jun 2009

Abstract excerpt

INTRODUCTION: Endothelin (EDN) signalling plays a crucial role in cell differentiation, proliferation and migration processes. There is compelling evidence that altered EDN signalling is involved in carcinogenesis by modulating cell survival and promoting invasiveness. To date, most reports have focused on the oncogenic potential of EDN1 and EDN2, both of which are overexpressed in various tumour entities. Here,...

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PMID: 19527488
DOI: 10.1186/bcr2319

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