Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.

The New England journal of medicine - 9 May 2013

Maxson Julia E, Gotlib Jason, Pollyea Daniel A, Fleischman Angela G, Agarwal Anupriya, Eide Christopher A, Bottomly Daniel, Wilmot Beth, McWeeney Shannon K, Tognon Cristina E, Pond J Blake, Collins Robert H, Goueli Basem, Oh Stephen T, Deininger Michael W, Chang Bill H, Loriaux Marc M, Druker Brian J, Tyner Jeffrey W

Abstract excerpt

BACKGROUND: The molecular causes of many hematologic cancers remain unclear. Among these cancers are chronic neutrophilic leukemia (CNL) and atypical (BCR-ABL1-negative) chronic myeloid leukemia (CML), both of which are diagnosed on the basis of neoplastic expansion of granulocytic cells and excl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Janus Kinases
Share to Leukemia, Lymphoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Kinase Inhibitors

Share to Protein-Tyrosine Kinases

Share to Receptors, Colony-Stimulating Factor

Share to RNA, Small Interfering

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 23656643
DOI: 10.1056/NEJMoa1214514
PMCID: PMC3730275

Genes

ABL1
BCR
JAK1
SRC
TNK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23656643-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.PMID 23656643Read ↗

The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment.Semantic proximity Read ↗

CSF3R mutated myeloid neoplasms: Beyond chronic neutrophilic leukemia.Semantic proximity Read ↗

Analysis of CSF3R mutations in atypical chronic myeloid leukemia and other myeloid malignancies.Semantic proximity Read ↗

CSF3R is mutated in chronic neutrophilic leukemia and atypical CML.Semantic proximity Read ↗

The molecular genetics of chronic neutrophilic leukaemia: defining a new era in diagnosis and therapy.Semantic proximity Read ↗

Expanding the Spectrum of CSF3R Mutated Myeloid Neoplasm Beyond Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia: A Comprehensive Analysis of 13 CasesSemantic proximity Read ↗

The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I.Semantic proximity Read ↗

Chronic neutrophilic leukemia: novel mutations and their impact on clinical practice.Semantic proximity Read ↗

What's different about atypical CML and chronic neutrophilic leukemia?Semantic proximity Read ↗

Targeted next-generation sequencing identifies clinically relevant mutations in patients with chronic neutrophilic leukemia at diagnosis and blast crisis.Semantic proximity Read ↗

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibitionSemantic proximity Read ↗

CSF3R Mutations are frequently associated with abnormalities of RUNX1, CBFB, CEBPA, and NPM1 genes in acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.