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Article

OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis.

Pharmacogenetics and genomics - 1 Jul 2013

Tamraz Bani, Fukushima Hisayo, Wolfe Alan R, Kaspera Rüdiger, Totah Rheem A, Floyd James S, Ma Benjamin, Chu Catherine, Marciante Kristin D, Heckbert Susan R, Psaty Bruce M, Kroetz Deanna L, Kwok Pui-Yan

Abstract excerpt

OBJECTIVE: Genetic variation in drug metabolizing enzymes and membrane transporters as well as concomitant drug therapy can modulate the beneficial and the deleterious effects of drugs. We investigated whether patients exhibiting rhabdomyolysis who were taking cerivastatin possess functional genetic variants in SLCO1B1 and whether they were on concomitant medications that inhibit OATP1B1, resulting in...

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Identifiers

PMID: 23652407
DOI: 10.1097/FPC.0b013e3283620c3b
PMCID: PMC3894639

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