Article
The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning.
Developmental biology - 1 Sept 2017
Olivares Ana Maria, Han Yinan, Soto David, Flattery Kyle, Marini Joseph, Mollema Nissa, Haider Ali, Escher Pascal, DeAngelis Margaret M, Haider Neena B
Abstract excerpt
Nuclear hormone receptors play a major role in the development of many tissues. This study uncovers a novel role for testicular receptor 2 (Tr2, Nr2c1) in defining the early phase of retinal development and regulating normal retinal cell patterning and topography. The mammalian retina undergoes an overlapping yet biphasic period of development to generate all seven retinal cell types. We discovered that Nr2c1...
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