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Article

Frequent adaptation and the McDonald-Kreitman test.

Proceedings of the National Academy of Sciences of the United States of America - 21 May 2013

Messer Philipp W, Petrov Dmitri A

Abstract excerpt

Population genomic studies have shown that genetic draft and background selection can profoundly affect the genome-wide patterns of molecular variation. We performed forward simulations under realistic gene-structure and selection scenarios to investigate whether such linkage effects impinge on the ability of the McDonald-Kreitman (MK) test to infer the rate of positive selection (α) from polymorphism and...

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PMID: 23650353
DOI: 10.1073/pnas.1220835110
PMCID: PMC3666677

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