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MKado: a toolkit for McDonald-Kreitman tests of natural selection.

G3 (Bethesda, Md.) - 5 Aug 2026

Rivera-Colón Angel G, Rehmann Clara T, Kern Andrew D

Abstract excerpt

MKado is a Python toolkit for performing McDonald-Kreitman (MK) tests of natural selection from aligned coding sequences. It implements the standard MK test as well as a wide variety of its extensions and related statistics, including a number of methods for estimating the fraction of adaptive substitutions (α) while accounting for slightly deleterious mutations, with a unified command-line interface and Python...

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Identifiers

PMID: 42219615
DOI: 10.1093/g3journal/jkag142
PMCID: PMC13439947

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