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Cytomegalovirus UL97 Kinase Mutations That Confer Maribavir Resistance

1 Jun 2007

Abstract excerpt

The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir (MBV) is undergoing clinical antiviral trials. Two clinical CMV isolates serially passaged in cell culture under MBV showed >20-fold increases in MBV resistance after the development of the UL97 mutation V353A in one of the isolates and of T409M in the other. Marker transfer studies confirmed that the V353A and T409M mutations conferred ~15-fold and...

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PMID: 17538888
DOI: 10.1086/518514

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