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Article

The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databank.

Journal of viral hepatitis - 1 Jun 2013

Alves R, Queiroz A T L, Pessoa M G, da Silva E F, Mazo D F C, Carrilho F J, Carvalho-Filho R J, de Carvalho I M V G

Abstract excerpt

Several new direct-acting antiviral (DAA) drugs are in development for chronic hepatitis C viral (HCV) infection, and NS3-NS4A serine protease and the NS5B RNA-dependent RNA polymerase have been the major targets. HCV variants displaying drug-resistant phenotypes have been observed both in vitro and during clinical trials. Our aim was to characterize amino acid changes at positions previously associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Drug Resistance, Viral

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Share to Protease Inhibitors

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Source

Identifiers

PMID: 23647958
DOI: 10.1111/jvh.12051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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