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Article

Cell surface rescue of kidney anion exchanger 1 mutants by disruption of chaperone interactions.

The Journal of biological chemistry - 22 Oct 2010

Patterson Sian T, Reithmeier Reinhart A F

Abstract excerpt

Mutations in the human kidney anion exchanger 1 (kAE1) membrane glycoprotein cause impaired urine acidification resulting in distal renal tubular acidosis (dRTA). Dominant and recessive dRTA kAE1 mutants exhibit distinct trafficking defects with retention in the endoplasmic reticulum (ER), Golgi, or mislocalization to the apical membrane in polarized epithelial cells. We examined the interaction of kAE1 with the...

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Share to Anion Exchange Protein 1, Erythrocyte
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Share to Elliptocytosis, Hereditary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

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Source

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Identifiers

PMID: 20628050
DOI: 10.1074/jbc.M110.144261
PMCID: PMC2963362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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