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Article

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.

PloS one - 1 Jan 2014

Mirabella Fabio, Murison Alexander, Aronson Lauren I, Wardell Christopher P, Thompson Andrew J, Hanrahan Sarah J, Fok Jacqueline H L, Pawlyn Charlotte, Kaiser Martin F, Walker Brian A, Davies Faith E, Morgan Gareth J

Abstract excerpt

The chromosomal translocation t(4;14) deregulates MMSET (WHSC1/NSD2) expression and is a poor prognostic factor in multiple myeloma (MM). MMSET encodes two major protein isoforms. We have characterized the role of the shorter isoform (REIIBP) in myeloma cells and identified a clear and novel interaction of REIIBP with members of the SMN (survival of motor neuron) complex that directly affects the assembly of the...

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Share to Chromosomes, Human, Pair 14
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

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Share to Ribonucleoproteins, Small Nuclear

Share to RNA Processing, Post-Transcriptional

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Source

Open in PubMed Open full text

Identifiers

PMID: 24923560
DOI: 10.1371/journal.pone.0099493
PMCID: PMC4055699

Genes

NSD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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