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Article

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.

PloS one - 1 Jan 2014

Mirabella Fabio, Murison Alexander, Aronson Lauren I, Wardell Christopher P, Thompson Andrew J, Hanrahan Sarah J, Fok Jacqueline H L, Pawlyn Charlotte, Kaiser Martin F, Walker Brian A, Davies Faith E, Morgan Gareth J

Abstract excerpt

The chromosomal translocation t(4;14) deregulates MMSET (WHSC1/NSD2) expression and is a poor prognostic factor in multiple myeloma (MM). MMSET encodes two major protein isoforms. We have characterized the role of the shorter isoform (REIIBP) in myeloma cells and identified a clear and novel inte...

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Share to Chromosomes, Human, Pair 14
Share to Chromosomes, Human, Pair 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Multiple Myeloma

Share to Ribonucleoproteins, Small Nuclear

Share to RNA Processing, Post-Transcriptional

Share to SMN Complex Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 24923560
DOI: 10.1371/journal.pone.0099493
PMCID: PMC4055699

Genes

NSD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24923560-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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