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Article

Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma.

The Journal of clinical investigation - 1 Sept 2007

Song Liping, Ara Tasnim, Wu Hong-Wei, Woo Chan-Wook, Reynolds C Patrick, Seeger Robert C, DeClerck Yves A, Thiele Carol J, Sposto Richard, Metelitsa Leonid S

Abstract excerpt

Valpha24-invariant natural killer T (NKT) cells are potentially important for antitumor immunity. We and others have previously demonstrated positive associations between NKT cell presence in primary tumors and long-term survival in distinct human cancers. However, the mechanism by which aggressive tumors avoid infiltration with NKT and other T cells remains poorly understood. Here, we report that the v-myc...

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Source

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Identifiers

PMID: 17710228
DOI: 10.1172/JCI30751
PMCID: PMC1940236

Genes

MYCN
CCL2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma.PMID 17710228Read ↗

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacySemantic proximity Read ↗

MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in NeuroblastomaSemantic proximity Read ↗

Metastasis in neuroblastoma: the MYCN questionSemantic proximity Read ↗

Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk MYCN -Not-Amplified Human NeuroblastomaSemantic proximity Read ↗

Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in NeuroblastomaSemantic proximity Read ↗

A Genome-Wide Search for Promoters That Respond to Increased MYCN Reveals Both New Oncogenic and Tumor Suppressor MicroRNAs Associated with Aggressive NeuroblastomaSemantic proximity Read ↗

The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic PotentialSemantic proximity Read ↗

Inhibition of CDK4 as a potential therapy for natural killer cell lymphoma with MYC overexpressionSemantic proximity Read ↗

Anti-GD2 antibody therapy alters the neuroblastoma tumor microenvironment and extends survival in <i>TH-MYCN</i> miceSemantic proximity Read ↗

Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYCSemantic proximity Read ↗

Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastomaSemantic proximity Read ↗

The <i>MYCN</i> Enigma: Significance of <i>MYCN</i> Expression in NeuroblastomaSemantic proximity Read ↗

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