Article
Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma.
The Journal of clinical investigation - 1 Sept 2007
Song Liping, Ara Tasnim, Wu Hong-Wei, Woo Chan-Wook, Reynolds C Patrick, Seeger Robert C, DeClerck Yves A, Thiele Carol J, Sposto Richard, Metelitsa Leonid S
Abstract excerpt
Valpha24-invariant natural killer T (NKT) cells are potentially important for antitumor immunity. We and others have previously demonstrated positive associations between NKT cell presence in primary tumors and long-term survival in distinct human cancers. However, the mechanism by which aggressive tumors avoid infiltration with NKT and other T cells remains poorly understood. Here, we report that the v-myc...
Topics
- Animals
- Bone Marrow
- Cell Movement
- Cells, Cultured
- Chemokine CCL2
- Female
- Gene Expression Regulation
- Humans
- Mice
- Mice, SCID
- N-Myc Proto-Oncogene Protein