Article
Interactive effects of smoking and glutathione S-transferase polymorphisms on the development of non-alcoholic fatty liver disease.
Toxicology letters - 4 Jul 2013
Oniki Kentaro, Hori Masaharu, Saruwatari Junji, Morita Kazunori, Kajiwara Ayami, Sakata Misaki, Mihara Shuichi, Ogata Yasuhiro, Nakagawa Kazuko
Abstract excerpt
Glutathione S-transferases (GSTs) protect cells against exogenous and endogenous oxidative stress. GST polymorphisms are associated with the development of cardiovascular disease (CVD) and diabetes mellitus (DM), especially in current-smokers. Non-alcoholic fatty liver disease (NAFLD) is a predictor of future CVD or DM, because oxidative stress contributes to their pathogenesis. This study investigated whether...
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