Article
Association of genetic polymorphisms of glutathione-S-transferase genes (GSTT1, GSTM1, and GSTP1) and susceptibility to nonalcoholic fatty liver disease in Zahedan, Southeast Iran.
DNA and cell biology - 1 May 2012
Hashemi Mohammad, Eskandari-Nasab Ebrahim, Fazaeli Aliakbar, Bahari Ali, Hashemzehi Noor-Allah, Shafieipour Sara, Taheri Mohsen, Moazeni-Roodi Abdolkarim, Zakeri Zahra, Bakhshipour Alireza, Ghavami Saeid
Abstract excerpt
Oxidative damage is thought to play a pivotal role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Glutathione-S-transferases (GSTs) are involved in cell protection against oxidative stress. We examined whether GSTM1, GSTT1, and GSTP1 polymorphisms are associated with NAFLD in a sample of the Iranian population. The current case-control study included 83 patients with NAFLD and 93 healthy...
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