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Article

PPARG gene Pro12Ala variant contributes to the development of non-alcoholic fatty liver in middle-aged and older Chinese population.

Molecular and cellular endocrinology - 2 Jan 2012

Yang Zhen, Wen Jie, Li Qin, Tao Xiaoming, Ye Zi, He Min, Zhang Weiwei, Huang Ying, Chen Lili, Ling Charlotte, Qu Shen, Hu Renming

Abstract excerpt

Oxidative stress has been suggested to contribute to the development of non-alcoholic fatty liver disease (NAFLD). Peroxisome proliferator-activated receptor gamma (PPAR-γ) heterozygous mice and Pro12Ala (C/G) polymorphism in PPARG exhibited increased resistance to oxidative stress. Smoking increases the production of reactive oxygen species, which could accelerates oxidative stress under overnutrition. To...

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Source

Identifiers

PMID: 21939732
DOI: 10.1016/j.mce.2011.09.001

Genes

PPARG

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PPARG gene Pro12Ala variant contributes to the development of non-alcoholic fatty liver in middle-aged and older Chinese population.PMID 21939732Read ↗

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