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Article

Mitochondrial dysfunction in glaucoma: understanding genetic influences.

Mitochondrion - 1 Mar 2012

Lascaratos Gerassimos, Garway-Heath David F, Willoughby Colin E, Chau Kai-Yin, Schapira Anthony H V

Abstract excerpt

Glaucoma is the leading cause of irreversible blindness worldwide. This review aims to provide a greater understanding of the complex genetic influences that may lead to mitochondrial dysfunction and increase susceptibility to retinal ganglion cell (RGC) loss in primary open angle glaucoma (POAG), and thus elucidate potentially important pathophysiological pathways amenable to therapeutic intervention. Emerging...

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Share to MFN2 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Source

Identifiers

PMID: 22138560
DOI: 10.1016/j.mito.2011.11.004

Genes

MFN1
MFN2
NOS3
OPA1
PARL
SOD2
SRBD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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