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Article

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

30 Apr 2013

Abstract excerpt

The complex of Vacuolar Protein Sorting 34 and 15 (Vps34 and Vps15) has Class III phosphatidylinositol 3-kinase activity and putative roles in nutrient sensing, mammalian Target Of Rapamycin (mTOR) activation by amino acids, cell growth, vesicular trafficking and autophagy. Contrary to expectations, here we show that Vps15-deficient mouse tissues are competent for LC3-positive autophagosome formation and maintain...

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PMID: 23630012
DOI: 10.1002/emmm.201202057

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