Article
Receiver operating characteristic analysis of HLA, CTLA4, and insulin genotypes for type 1 diabetes.
Diabetes care - 1 Sept 2013
Valdes Ana M, Varney Michael D, Erlich Henry A, Noble Janelle A
Abstract excerpt
OBJECTIVE: This study assessed the ability to distinguish between type 1 diabetes-affected individuals and their unaffected relatives using HLA and single nucleotide polymorphism (SNP) genotypes. RESEARCH DESIGN AND METHODS: Eight models, ranging from only the high-risk DR3/DR4 genotype to all significantly associated HLA genotypes and two SNPs mapping to the cytotoxic T-cell-associated antigen-4 gene (CTLA4) and...
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