Article
Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy.
American journal of respiratory and critical care medicine - 15 Nov 2010
Suzuki Takuji, Sakagami Takuro, Young Lisa R, Carey Brenna C, Wood Robert E, Luisetti Maurizio, Wert Susan E, Rubin Bruce K, Kevill Katharine, Chalk Claudia, Whitsett Jeffrey A, Stevens Carrie, Nogee Lawrence M, Campo Ilaria, Trapnell Bruce C
Abstract excerpt
RATIONALE: We identified a 6-year-old girl with pulmonary alveolar proteinosis (PAP), impaired granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor function, and increased GM-CSF. OBJECTIVES: Increased serum GM-CSF may be useful to identify individuals with PAP caused by GM-CSF receptor dysfunction. METHODS: We screened 187 patients referred to us for measurement of GM-CSF autoantibodies to diagnose...
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