Article
The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α.
Inflammatory bowel diseases - 1 May 2013
Ueda Naoyasu, Tsukamoto Hiroshi, Mitoma Hiroki, Ayano Masahiro, Tanaka Atsushi, Ohta Shun-ichiro, Inoue Yasushi, Arinobu Yojiro, Niiro Hiroaki, Akashi Koichi, Horiuchi Takahiko
Abstract excerpt
BACKGROUND: Anti-tumor necrosis factor α (anti-TNF-α) agents have been successfully applied for the treatment of rheumatoid arthritis, Crohn's disease, and other chronic inflammatory diseases. Not only the neutralization of soluble TNF-α but also the effect on transmembrane TNF-α is important mechanisms of action of anti-TNF-α agents. This study investigated the cytotoxic effects of new anti-TNF-α agents,...
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