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Article

Infliximab downregulates interferon-gamma production in activated gut T-lymphocytes from patients with Crohn's disease.

Cytokine - 21 Aug 2001

Agnholt J, Kaltoft K

Abstract excerpt

The tumour necrosis factor-alpha (TNF-alpha) neutralizing antibody, Infliximab (Ifx), reduces disease activity in patients with active steroid-dependent or fistulizing Crohn's disease. The mechanisms underlying the effects of Ifx are not fully understood. This study aims to investigate if and how Ifx regulates the interferon-gamma (IFN-gamma) production in human intestinal T-cells. Colonic T cells were expanded...

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Source

Identifiers

PMID: 11563881
DOI: 10.1006/cyto.2001.0919

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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