Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of TNF-α in mitochondrial diseases caused by mutations in mtDNA: evidence for signaling through its receptors on mitochondria.

Free radical biology & medicine - 1 Oct 2013

Vattemi Gaetano, Marini Matteo, Ferreri Nicholas R, Hao Shoujin, Malatesta Manuela, Meneguzzi Alessandra, Guglielmi Valeria, Fava Cristiano, Minuz Pietro, Tomelleri Giuliano

Abstract excerpt

Mitochondrial diseases (MDs) are heterogeneous disorders due to impaired respiratory chain function causing defective ATP production. Although the disruption of oxidative phosphorylation is central to the MD pathophysiology, other factors may contribute to these disorders. We investigated the expression and the cellular localization of TNF-α and its receptors, TNFR1 and TNFR2, in muscle biopsies from 15 patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mitochondrial Diseases

Share to Oxidative Phosphorylation

Share to Receptors, Tumor Necrosis Factor, Type I

Share to Receptors, Tumor Necrosis Factor, Type II

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 23619127
DOI: 10.1016/j.freeradbiomed.2013.04.025

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of TNF-α in mitochondrial diseases caused by mutations in mtDNA: evidence for signaling through its receptors on mitochondria.PMID 23619127Read ↗

Tumor Necrosis Factor-α Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle CellsSemantic proximity Read ↗

TNF-related ligands and their receptors.Semantic proximity Read ↗

Tumour Necrosis Receptor Superfamily Interact with the Mitochondrial Dynamics in Adipose Tissue in Obese Patients without Type 2 DiabetesSemantic proximity Read ↗

TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cellsSemantic proximity Read ↗

Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis.Semantic proximity Read ↗

A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytesSemantic proximity Read ↗

Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis.Semantic proximity Read ↗

Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study.Semantic proximity Read ↗

Transmembrane Tumor Necrosis Factor (TNF)-α Inhibits Adipocyte Differentiation by Selectively Activating TNF Receptor 1Semantic proximity Read ↗

Physiological role of tumor necrosis factor alpha in traumatic muscle injury.Semantic proximity Read ↗

Monocytic fasciitis: a newly recognized clinical feature of tumor necrosis factor receptor dysfunction.Semantic proximity Read ↗

Association study of the tumor necrosis factor-alpha gene and its 1A receptor gene with methamphetamine dependence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.