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Article

Aberrant anaplastic lymphoma kinase expression in high-grade pulmonary neuroendocrine carcinoma

25 Apr 2013

Abstract excerpt

AIMS: In lung cancer with anaplastic lymphoma kinase (ALK) gene rearrangement, accurate diagnosis is essential to identify patients who can be treated with a specific kinase inhibitor. Sensitive ALK immunostaining can provide nearly complete concordance with gene rearrangement status and is expected to serve as a surrogate biomarker for tailored treatment with an ALK inhibitor. In the present report, we describe...

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PMID: 23618692
DOI: 10.1136/jclinpath-2012-201329

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