Article
Canine distemper virus infection leads to an inhibitory phenotype of monocyte-derived dendritic cells in vitro with reduced expression of co-stimulatory molecules and increased interleukin-10 transcription.
PloS one - 1 Jan 2014
Qeska Visar, Barthel Yvonne, Herder Vanessa, Stein Veronika M, Tipold Andrea, Urhausen Carola, Günzel-Apel Anne-Rose, Rohn Karl, Baumgärtner Wolfgang, Beineke Andreas
Abstract excerpt
Canine distemper virus (CDV) exhibits a profound lymphotropism that causes immunosuppression and increased susceptibility of affected dogs to opportunistic infections. Similar to human measles virus, CDV is supposed to inhibit terminal differentiation of dendritic cells (DCs), responsible for disturbed repopulation of lymphoid tissues and diminished antigen presenting function in dogs. In order to testify the...
Topics
- Animals
- Antigen Presentation
- Cell Shape
- Cells, Cultured
- Dendritic Cells
- Distemper
- Distemper Virus, Canine
- Dogs
- Interleukin-10
- L-Lactate Dehydrogenase