Article
Overexpression of MicroRNA-1 improves the efficacy of mesenchymal stem cell transplantation after myocardial infarction.
Cardiology - 1 Jan 2013
Huang Feng, Li Mei-Ling, Fang Zhen-Fei, Hu Xin-Qun, Liu Qi-Ming, Liu Zhen-Jiang, Tang Liang, Zhao Yan-Shu, Zhou Sheng-Hua
Abstract excerpt
BACKGROUND: The aim of this research was to study whether transplantation of mesenchymal stem cells (MSCs) overexpressing microRNA-1 into mouse infarcted myocardium can enhance cardiac myocyte differentiation and improve cardiac function efficiently. METHODS: Eight-week-old female C57BL/6 mice underwent ligation of the left coronary artery to produce models of myocardial infarction. The ligated animals were...
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