Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model.

doi:10.1016/j.healun.2014.05.008

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Article

Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Oct 2014

Liu Xianbao, Chen Huiqiang, Zhu Wei, Chen Han, Hu Xinyang, Jiang Zhi, Xu Yinchuan, Zhou Yu, Wang Kan, Wang Lihan, Chen Panpan, Hu Hengxun, Wang Chen, Zhang Na, Ma Qunchao, Huang Mingyuan, Hu Dexing, Zhang Ling, Wu Rongrong, Wang Yaping, Xu Qiyuan, Yu Hong, Wang Jian'an

Abstract excerpt

BACKGROUND: Previous studies have demonstrated that biological aging has a negative influence on the therapeutic effects of mesenchymal stem cells (MSCs)-based therapy. Using a rat myocardial infarction (MI) model, we tested the hypothesis that silent mating type information regulation 2 homolog 1 (SIRT1) may ameliorate the phenotype and improve the function of aged MSCs and thus enhance the efficacy of aged...

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Identifiers

PMID: 25034794
DOI: 10.1016/j.healun.2014.05.008

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SIRT1
MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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