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Article

Methionine synthase A2756G polymorphism and risk of colorectal adenoma and cancer: evidence based on 27 studies.

PloS one - 1 Jan 2013

Ding Weixing, Zhou Dong-Lei, Jiang Xun, Lu Lie-Sheng

Abstract excerpt

Methionine synthase (MTR), which plays a central role in maintaining adequate intracellular folate, methionine and normal homocysteine concentrations, was thought to be involved in the development of colorectal cancer (CRC) and colorectal adenoma (CRA) by affecting DNA methylation. However, studies on the association between MTR A2756G polymorphism and CRC/CRA remain conflicting. We conducted a meta-analysis of...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23593229
DOI: 10.1371/journal.pone.0060508
PMCID: PMC3621882

Genes

MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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