Article
EZH2 mutations are related to low blast percentage in bone marrow and -7/del(7q) in de novo acute myeloid leukemia.
PloS one - 1 Jan 2013
Wang Xiuli, Dai Haiping, Wang Qian, Wang Qinrong, Xu Yang, Wang Ying, Sun Aining, Ruan Jia, Chen Suning, Wu Depei
Abstract excerpt
The purpose of the present work was to determine the incidence and clinical implications of somatic EZH2 mutations in 714 patients with de novo acute myelogenous leukemia by sequencing the entire coding region. EZH2 mutations were identified in 13/714 (1.8%) of AML patients were found to be more common in males (P = 0.033). The presence of EZH2 mutations was significantly associated with lower blast percentage...
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