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Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients.

Clinical epigenetics - 12 Apr 2021

Stomper Julia, Meier Ruth, Ma Tobias, Pfeifer Dietmar, Ihorst Gabriele, Blagitko-Dorfs Nadja, Greve Gabriele, Zimmer Dennis, Platzbecker Uwe, Hagemeijer Anne, Schmitt-Graeff Ingrid, Lübbert Michael

Abstract excerpt

BACKGROUND: Mutations in the EZH2 gene are recurrently found in patients with myeloid neoplasms and are associated with a poor prognosis. We aimed to characterize genetic and epigenetic alterations of EZH2 in 58 patients (51 with acute myeloid leukemia and 7 with myelodysplastic or myeloproliferative neoplasms) by integrating data on EZH2 mutational status, co-occurring mutations, and EZH2 copy number status with...

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Cohort Studies
DNA Copy Number Variations
Enhancer of Zeste Homolog 2 Protein
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Myeloid, Acute

Myelodysplastic Syndromes

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Identifiers

PMID: 33845873
DOI: 10.1186/s13148-021-01052-2
PMCID: PMC8043064

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