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Article

Reprogramming the Cell Cycle for Endoreduplication in Rodent Trophoblast Cells

1 Apr 1998

Abstract excerpt

Differentiation of trophoblast giant cells in the rodent placenta is accompanied by exit from the mitotic cell cycle and onset of endoreduplication. Commitment to giant cell differentiation is under developmental control, involving down-regulation of Id1 and Id2, concomitant with up-regulation of the basic helix-loop-helix factor Hxt and acquisition of increased adhesiveness. Endoreduplication disrupts the...

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PMID: 9529378
DOI: 10.1091/mbc.9.4.795

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